Presentations

Saturday, 21 September
Welcome and Introductions
Opening Remarks
Peter Hillmen
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History of CLL
Gerald Marti
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Session 1:
The CLL (Epi)genome
Chair(s): Christopher Oakes, and Tatjana Stankovic
Overview of the CLL Genome
Jonathan Strefford
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The Epigenetic Features of CLL:
DNA Methylation
Christoph Plass
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Insights From Tertiary Structure, Chromatin
Modifications, and Nuclear Organization
José Ignacio Martín-Subero
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*Comprehensive genomic testing for chronic lymphocytic leukaemia patients: WGS, one key to patient stratification (2086)
Kate Ridout
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*BIRC3 loss accelerates leukemic progression through activation of the non-canonical NF-kB signaling of del(11q) CLL cells (2133)
Miguel Quijada-Álamo
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**Leukemia specific delivery of miR29b induces epigenetic reprogramming with cell cycle arrest and therapeutic benefit in Chronic Lymphocytic Leukemia (2188)
Natarajan Muthusamy
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**Cooperation between SF3B1 mutation and ATM deletion in the development of CLL (2194)
Lili Wang
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Session 2:
The CLL (Epi)genome (cont.)
Chair(s): Sarka Pospisilova, and Deepa Sampath
Keynote
Evolution and Mathematical Modelling of
Cancer Genomes
Gad Getz
Presentation
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Functional Implications of Genomic Lesions
Catherine Wu
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The Impact of Regulatory RNA Molecules
Marek Mráz
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ATM: Pathway, Lesions, and Targeting
Tatjana Stankovic
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*Effect of second-generation BTK inhibitors on the functionality of macrophages and neutrophils from CLL patients. (2088)
Mercedes Borge
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*Pyroptosis as a drugable cell death pathway in Chronic Lymphocytic Leukemia: The other side of inflammation. (2052)
Pablo Oppezzo
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**Clinical impact of clonal and subclonal TP53 mutations and deletions in chronic lymphocytic leukemia: an Italian multicenter experience (2130)
Riccardo Bomben
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**Minor-clone TP53 mutations in CLL patients entering first-line treatment: clonal evolution and clinical impact (2136)
Jitka Malcikova
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Session 3: The B-Cell Receptor
Chair(s): Andrew Steele, and Jan Burger
Role of the B-Cell Receptor in B-Cell
Oncogenesis
Stefano Casola
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Dissecting CLL Immunogenetics and
Emerging B-Cell Receptor Stereotypes
Kostas Stamatopoulos
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CLL-Specific Aspects of B-Cell Receptor
Signaling
Graham Packham
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*Using signal-omics to fingerprint the impact of antigen engagement and therapy on BCR activation in CLL. (1904)
Adam Linley
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*Functional interplay between the B-cell receptor and NOTCH1 in Chronic Lymphocytic Leukemia and in Richter’s syndrome (2065)
Francesca Arruga
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**Targeting MDSCs in CLL-bearing mice by suppressing the synthesis of secretory IgM via activation of RIDD (1987)
Chih-Chi Hu
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**Ibrutinib therapy downregulates AID enzyme and proliferative fractions in chronic lymphocytic leukemia (2047)
Pablo Morande
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**Distinct Immune Signatures in Chronic Lymphocytic Leukemia and Richter Syndrome (2062)
Yucai Wang
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Session 4: Microenvironment and Models of CLL
Chair(s): Christopther Pepper, and Varsha Gandhi
Linking the Microenvironment With CLL
Models
Nicholas Chiorazzi
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In Vitro Modelling of the CLL
Microenvironment
Alan Ramsay
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Murine and Xenograft Models of CLL
Shih-Shih Chen
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Role of NOTCH1 in CLL and in Richter’s Transformation
Silvia Deaglio
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*Mechanisms of Ibrutinib resistance in the Eµ-TCL-1 mouse model of chronic lymphocytic leukemia (2124)
Martina Seiffert
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*3D-culture of CLL cells in bioreactor identifies the bone marrow as a key regulator of HS1 function in response to Ibrutinib (1932)
Cristina Scielzo
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**Analyzing the mutational landscape of two CLL mouse models overexpressing AID identifies proliferative fraction-associated tumor genes involved in leukemic development and progression (2049)
Pablo Morande
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**Modelling Chronic Lymphocytic Leukemia microenvironment in vitro by exploiting newly-established 3D systems (2006)
Francesca Vittoria Sbrana
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**Chronic lymphocytic leukemia remodels the fibroblastic reticular network that contributes to immunosuppression in the tumor microenvironment (2166)
Natalia Couto-Francisco
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**IL10-producing CD38hi B-regulatory cells drive the immunosuppressive microenvironment in CLL and can be targeted with anti-CD38 immunotherapy (2193)
Alak Manna
Presentation
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Sunday, 22 September
Session 5: Innovations in the Assessment of CLL
Chair(s): Alessandra Ferrajoli, and Nicole Lamanna
Laboratory Assessment of CLL, Including MRD
as an End Point
Andrew Rawstron
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Molecular Characterization of CLL
Richard Rosenquist Brandell
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Clinical Assessment of CLL
Carol Moreno
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Critical Assessment and New Development of
Prognostic Scoring Systems
Barbara Eichhorst
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*Gene expression signatures predict time-to-progression after front-line chemoimmunotherapy for CLL (1925)
Kevin Coombes
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*Ibrutinib versus placebo in patients with asymptomatic, treatment-naïve early stage chronic lymphocytic leukemia (CLL): primary endpoint results of the phase 3 double-blind randomized CLL12 trial. (1938)
Petra Langerbeins
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**Undetectable minimal residual disease should be the goal of venetoclax therapy in relapsed and refractory chronic lymphocytic leukaemia (2089)
Thomas Lew
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**Predicting tumor lysis syndrome in venetoclax-treated CLL patients (2008)
Anthony Mato
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Session 6:
Initial Therapy
Chair(s): Steven Coutre, and Adrian Bloor
Early Intervention: Can We Justify It and What
End Points Should We Consider?
Petra Langerbeins
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Current Initial Treatment of CLL – for Young
Patients
Florence Cymbalista
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Current Initial Treatment of CLL – for Elderly
Patients
Valentin Goede
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Treatment of CLL from 2019 Onwards: E1912 Trial
Tait Shanafelt
Presentation
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Treatment of CLL from 2019 Onwards: Alliance Trial
Danielle Brander
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Treatment of CLL from 2019 Onwards: iLLUMINATE Trial
Alessandra Tedeschi
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Treatment of CLL from 2019 Onwards: CLL14 Trial
Kirsten Fischer
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*Ibrutinib for first-line treatment of chronic lymphocytic leukemia in patients aged ≥65 year of age: results with 5 years of follow-up for the RESONATE-2 study (1956)
Alessandra Tedeschi
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*Obinutuzumab and ibrutinib treatment induction followed by a minimal residual disease-driven strategy in chronic lymphocytic leukaemia: long-term results in the ICLL-07 FILO trial (1962)
Anne-Sophie Michallet
Presentation
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**Obinutuzumab as consolidation after chemo-immunotherapy is highly effective in achieving MRD clearance from bone marrow and peripheral blood resulting in improved Progression-free survival: Results of UK NCRI Phase II/III GALACTIC trial (2121)
Talha Munir
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**Long-term efficacy and safety of maintenance with lenalidomide in patients with chronic lymphocytic leukaemia and a high risk of progression after first-line immunochemotherapy (2017)
Moritz Fürstenau
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Keynote
Overview of Clonal Evolution and Genomic Instability in CLL and Implications for Therapy
Daniel Landau
Presentation
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Session 7:
Resistance Mechanisms
Chair(s): Bryone Kuss, and Loic Ysebaert
Development of Resistance to B-Cell Receptor
Inhibition
Jennifer Woyach
Presentation
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Development of Resistance to BCL2 Inhibition
Mary Ann Anderson
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*Prevalence of BTK and PLCG2 mutations in chronic lymphocytic leukemia patients relapsing on ibrutinib: a European Research Initiative on CLL (ERIC) real-world study (2098)
Lesley-Ann Sutton
Presentation
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*High surface tumor IgM levels associate with reduced response duration and with BTK bypass during ibrutinib therapy in CLL patients (2195)
Giorgia Chiodin
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**CD8+ T-cell exhaustion induced by leukemic cells mediates progression in Chronic Lymphocytic Leukemia (CLL) (2096)
Isabel Jiménez
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Binet/Rai Medal Presentation Presentation
Not Available
Monday, 23 September
Session 8:
Therapy of Relapsed/Refractory CLL
Chair(s): Jacqueline Barrientos, and Barbara Eichhorst
B-Cell Receptor-Inhibitor Therapy in Relapsed/
Refractory Disease
Susan O’Brien
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BCL2-Inhibitor-Based Therapy and MRD in
Relapsed/Refractory Disease
John Seymour
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Novel Combinations and MRD in Relapsed/
Refractory Disease
Matthew Davids
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Defining Duration of Therapy: Is There a Role
for MRD?
Talha Munir
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*Venetoclax combined with ibrutinib based on a minimal residual disease-guided approach in relapsed/refractory chronic lymphocytic leukemia: results of the IMPROVE study (2068)
Lydia Scarfo
Presentation
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*Ibrutinib plus venetoclax in Relapsed/Refractory CLL: The CLARITY Study (2143)
Talha Munir
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**Biological responses to ibrutinib plus venetoclax in the Bloodwise TAP CLARITYstudy (2163)
Andrew Rawstron
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**Pneumocystis jirovecii pneumonia and invasive fungal infection incidence and institutional prophylaxis practices in CLL patients treated with BTK inhibitors (1941)
Christine Ryan
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Session 9:
Novel Strategies in Rel/Refr CLL
Chair(s): George Follows, and Adrian Wiestner
Evolution of Small Molecule Inhibitors:
New vs Old
John Byrd
Presentation
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Updates on Immune Therapy Strategies,
Including CAR T-Cell Therapy and Stem Cell
Transplant
Katy Rezvani
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*ASCEND Phase 3 study of acalabrutinib vs investigator’s choice of rituximab plus idelalisib (IdR) or bendamustine (BR) in patients with relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL) (2158)
Wojciech Jurczak
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*T cell bispecific antibody combination immunotherapy for chronic lymphocytic leukemia (2063)
Despoina Papazoglou
Presentation
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**A Phase 2 Study to Assess the Safety and Efficacy of Umbralisib in Patients with Chronic Lymphocytic Leukemia (CLL) who are Intolerant to Prior BTK or PI3K Delta Inhibitor Therapy (1943)
Danielle Brander
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**Biology and targeting of mutant p53 in CLL (2172)
Janani Ravikrishnan
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Debate: Future Management of CLL:
Is There a Role for Cellular Therapy?
Moderator: Anna Schuh
David Maloney (CAR T)
Johannes Schetelig (SCT)
Matt Davids (Novel-Novel)
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Session 10:
Real-World Data and Registries
Chair(s): Neil Kay, and Eva Kimby
CLL Clinical Genomics: Overview of the
National Programmes in Sweden, the US, the
UK, and France
Anna Schuh
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Geographic Diversity and Management of CLL
in South American Patients
Carlos Sérgio Chiattone
Presentation
Not Available
Geographic Diversity and Management of CLL
in African Patients
Norah Akinola
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Geographic Diversity and Management of CLL
in Indian Patients
Abraham Varghese
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Geographic Diversity and Management of CLL
in Chinese Patients
Shenmiao Yang
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Session 11:
iwCLL UPDATES
Chair: Peter Hillmen
Reorganization of the iwCLL
Michael Hallek
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An Update From the European Research
Initiative on CLL (ERIC)
Paolo Ghia
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Current Efforts From European and US
Real-World Data
Christopher Fox (EU) and Anthony Mato (US)
Presentation
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Closing Comments
Peter Hillmen
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